CONTEXT OF THE JOB

The Biswas-Fiss Laboratory of Translational Genetics, located in the Ammon Pinizzotto Biopharmaceutical Innovation Center at the University of Delaware, within the Department of Medical and Molecular Sciences at the University of Delaware College of Health Sciences, seeks a candidate for a Postdoctoral Position that can contribute to the mechanistic understanding of the cellular, molecular, and genetic mechanisms that govern ABCA4-linked retinal degenerative diseases (IRDs).

MAJOR RESPONSIBILITIES

This position's primary responsibilities are supporting studies related to the molecular genetics of inherited macular degeneration and translating this information into genotype-phenotype correlations.  ​Our research aims to utilize in vitro, in vivo , and computational tools to translate and reclassify the consequences of genetic variants of unknown significance (VUS).   This work will aid in the development of targeted therapies and help direct patients to appropriate clinical trials.    Specific duties include but are not limited to:

• Working in vitro, in vivo and computational models of disease.
• Collection, preparation, and analysis of research data. Spearhead studies focused on the consequences of ABCA4 genetic variants using ACMG/AMP-based metrics.
• Using appropriate biostatistical tools, correlating genetic, protein structure, and functional data with clinical profiles.
• Employing computational tools to evaluate the consequences of ABCA4 genetic variants.
• Employ and/or develop machine learning algorithms
• With the PI, interpret analyzed data to prepare for publication.
• Willingness to develop and implement new laboratory techniques when needed to test hypotheses and approach research questions.
• Writing research articles as first author and participating in publications as co-author.
• Presentation of scientific work at research conferences/symposiums.
• Working with basic science and clinical collaborators, including formulation of reports.
• Assisting with grant preparation and reporting but is not responsible for generating grant funds.
• Supervising and assisting with the training of graduate/undergraduate students and other lab personnel to coordinate research efforts for increased efficiency.
• Participating in research training programs as needed. Operating and maintaining equipment and instruments.

QUALIFICATIONS

• Ph.D. in Cell and Molecular Biology, Biochemistry, Computational Biology or a related Life Science background with a strong molecular biology focus.
• A strong publication record in reputed peer-reviewed journals.
• Prior experience working with in vitro and in vivo disease models, human genetics, computational biology, and complex large data analyses is a plus.
• Strong intellectual creativity, an ability to develop and lead projects independently, with a strong ability to work in a collaborative environment.
• Excellent scientific presentation and writing skills.
• Passionate about biomedical research and committed to pursuing innovative research questions for the benefit of the patients impacted by ABCA4-associated blinding disorders.