Scientist, Chemistry & Biochemistry
Job no: 494847
Work type: Staff
Categories: Research & Laboratory, Full Time
Pay Grade: 32E
Context of the job:
The expansion of Life Sciences and the development of the Biopharmaceutical Institute have increased the need for proteomic services across campus. To accommodate this need, The Mass Spectrometry Facility has recently undergone a significant expansion with the acquisition of six spectrometer systems, including UPLC-enabled Xevo G2-S QTof, Bruker MicroFlex MALDI-TOF and Thermo Q-Exactive Orbitrap systems. A leader in proteomics is needed. The Scientist (Director of Proteomics) will oversee day-to-day proteomics and protein chemistry approaches to support basic research across a variety of areas including cancer, microbiology, and neurobiology. The Scientist is responsible for guiding initiatives around proteomics and establishing a functional proteomics operation that will involve interfacing directly with faculty and student researchers, assuring that the methodology in the Mass Spectrometry Facility is state of the art and interacting with the proteomic community at large. The Scientist is also responsible for operating, maintaining and trouble-shooting instrumentation; training and supervising student users and assistants; collaborating with researchers to identify best methods and experimental designs, perform sample analysis with various software platforms, perform sample preparation and execution of a broad range of proteomic and protein MS work-flows in the design.
- Plans, organizes, directs, and coordinates research in obtaining and analyzing macromolecular/biomolecular mass spectrometric data for University research programs.
- Collaborates with the Mass Spectrometry Instrumentation Facility Manager to design and develop mass spectrometry research protocols to assist students, professionals and faculty in planning and interpreting experiments using the mass spectrometers, with particular emphasis on macromolecular/biomolecular/proteomic mass spectrometry.
- Assists researchers in facilitating projects; acts as a resource person for sample preparation and chromatographic separation in conjunction with mass spectrometry.
- Works with faculty and students to analyze and interpret data, provide technical expertise on the quality of data obtained and suggest potential follow-up studies.
- In collaboration with the Manager, oversees the daily operation of the Mass Spectrometry laboratory, particularly the macromolecular/biomolecular instruments, including scheduling of equipment, billing appropriate principal investigators and outside users, supervising and instructing students who are using the equipment, maintaining cryogen levels in the superconducting magnet and ensuring safe, efficient, clean and orderly operation.
- Develops and collaborates in the preparation of publications from Mass Spectrometry Core’s research and education projects.
- Writes grant proposals to acquire new instrumentation, co-authors scientific publications in peer-reviewed journals. Experimental design for critical experiments to fuel our research programs, education of the graduate and undergraduate population, maintains multimillion-dollar instrumentation.
- Organizes and teaches classes in mass spectrometry at the graduate level and helps set up the mass spectrometry laboratory experiments for undergraduate courses.
- Demonstrates mass spectrometric equipment as appropriate.
- Coordinates formal and informal hazard reviews of all lab research equipment and procedures in the Mass Spectrometry facility.
- Maintains and repairs instrumentation.
- Makes arrangements for necessary service calls, including repair and/or replacement of defective mechanical components.
- Evaluates, diagnoses and takes appropriate, cost-effective action to correct malfunctions of the instruments.
- Maintains contacts with manufacturers for instrument upgrades.
- Subject matter expert for all modern developments in macromolecular/biomolecular/proteomic mass spectrometric techniques, equipment and applications by attending appropriate short courses, seminars and exhibitions.
- Supervises spectrometry assistants, both research professionals and graduate students.
- Performs miscellaneous job-related duties as assigned.
- Ph.D. in chemistry, biochemistry or a related area with six years’ experience (either post-doctoral and/or industry in the field of proteomics), or equivalent combination of education experience.
- Familiarity with a wide range of ionization methods, mass analyzers and coupled chromatographic techniques used in chemical and biochemical research.
- Proficiency in bioinformatics approaches including protein quantification, statistical analyses, and pathway analysis.
- Effective communication skills, both oral and written.
- Ability to effectively interact with people of all ages and diverse backgrounds.
- Knowledge of research methodology, principles and procedures.
- Knowledge of the use and maintenance of equipment. Knowledge of electronics.
- Knowledge of current technological developments/trends in mass spectrometry.
- Ability to maintain expertise by reading the literature and attending scientific meetings.
- Ability to undertake independent or collaborative research.
- Ability to investigate and analyze information and to draw conclusions.
- Ability to gather and analyze statistical data and generate reports.
- Ability to understand, follow, and enforce safety procedures.
- Ability to design, organize, and coordinate scientific research projects.
- Ability to anticipate changing experimental demands, plan for acquisition of needed instrumentation, and establish new experimental procedures.
Applications will be reviewed beginning March 16, 2020.
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